Does Manipulation of Arterial Shear Stress Enhance Cerebrovascular Function and Cognition in the Aging Brain?

Grant number: 1045204 | Funding period: 2013 - 2016

Completed

Abstract

Globally, 9.2 million less cases of dementia could result from delaying it by as little as 12 months. We will assess the impact, on artery health and cognition, of a novel exercise intervention involving enhanced patterns of brain blood flow and arterial shear stress during exercise, stimuli which should optimise cerebrovascular health. Given that pharmacological approaches to prevention are ineffective, this project has the potential to address the future impact of this common and debilitating disease in Australians.

Related publications (7)

Scholarly works icon

Impact of Water- and Land-Based Exercise Training on Risk Factors and Vascular Function in Middle-Aged and Older Men and Women

DJ Green, GO Silva, KJ Smith, BA Maslen, KL Cox, NT Lautenschlager, CF Pestell, PN Ainslie, A Haynes, LH Naylor

2024-02-01

Introduction: Exercise improves vascular function, but it is unclear whether benefits are mediated by traditional cardiovascular r..

Scholarly works icon

The Impact of 6-Month Land versus Water Walking on Cerebrovascular Function in the Aging Brain

DJ Green, K Smith, BA Maslen, KAYL Cox, NT Lautenschlager, CF Pestell, LH Naylor, PN Ainslie, HH Carter

2021-10-01

Introduction To examine the hypothesis that exercise training induces adaptation in cerebrovascular function, we recruited 63 olde..

Scholarly works icon

Effects of Land versus Water Walking Interventions on Vascular Function in Older Adults

A Haynes, LH Naylor, AL Spence, E Robey, KL Cox, BA Maslen, NT Lautenschlager, HH Carter, PN Ainslie, DJ Green

2021-01-01

Purpose Endothelial dysfunction is an early and integral atherogenic event. Interventions that improve endothelial function also r..

Scholarly works icon

Land-walking vs. water-walking interventions in older adults: Effects on aerobic fitness

A Haynes, LH Naylor, HH Carter, AL Spence, E Robey, KL Cox, BA Maslen, NT Lautenschlager, ND Ridgers, DJ Green

2020-05-01

Background: Low cardiorespiratory fitness is an independent predictor of all-cause and cardiovascular mortality, and interventions..

Scholarly works icon

Land- versus water-walking interventions in older adults: Effects on body composition

LH Naylor, BA Maslen, KL Cox, AL Spence, E Robey, A Haynes, HH Carter, NT Lautenschlager, ND Ridgers, C Pestell, DJ Green

2020-02-01

Objectives: Increasing physical activity is a priority worldwide, including for older adults who may have difficulty performing tr..

Scholarly works icon

Does manipulation of arterial shear stress enhance cerebrovascular function and cognition in the aging brain? Design, rationale and recruitment for the Preventia randomised clinical trial

DJ Green, KL Cox, JC Badcock, PN Ainslie, C Pestell, BA Maslen, NT Lautenschlager

2018-10-01

Background: Cognitive and cerebrovascular declines are potentially life-changing conditions which are associated with a substantia..

Scholarly works icon

Relationship between monocyte-platelet aggregation and endothelial function in middle-aged and elderly adults

A Haynes, MD Linden, E Robey, LH Naylor, KL Cox, NT Lautenschlager, DJ Green

2017-05-01

Low-grade inflammation, endothelial dysfunction, and platelet hyper-reactivity to agonists are associated with an increased risk o..

University of Melbourne Researchers